Dexamethasone Intermediate CAS 24916-90-3 is a dehydrogenated chemical that can be utilized as an impurity standard during Dexamethasone commercial manufacture. It is commonly utilized in a wide range of pharmacological testing methodologies, including toxicity studies, FDA-approved Abbreviated New Drug Application (ANDA) submissions, and internal quality control/quality assurance.
The invention relates to the technological field of biological pharmacy, and more specifically to a method of generating Dexamethasone Epoxide Hydrolysate by one-step fermentation conversion. The procedure entails performing mixed fermentation using Arthrobacter simplex and Bacillus megatherium.
Dexamethasone is a well-known glucocorticoid medication having a variety of pharmacological effects, including antiinflammatory, antiallergic, and suppressive properties. It is used to treat conditions such as collagenosis, lupus erythematosus, and rheumatic heart disease. It can also be utilized as a life-saving medicine for critically unwell individuals. This is a common step in the synthesis of dexamethasone. It is also one of the most affordable. As a result, it is an excellent solution for your industrial projects. Please contact us if you have any queries regarding this product. We will be delighted to assist! Guidechem is here to help you find the best Dexamethasone Intermediate CAS 24916-90-3.
Dexamethasone Intermediate CAS 24916-90-3 is the world's most extensively used medication and a type of pharmaceutical intermediate. The glucocorticoid medication is clinically effective and has anti-inflammatory, anti-allergic, anti-oxidation, and suppressive actions. It is often used to treat collagenosis and rheumatoid arthritis. It is also used to treat lupus, myocarditis, and rheumatic heart disease.
This extremely important pharmacological intermediate is mostly produced from diene derivatized hydroxypregna-4-ene-9,11-epoxy-3,20-dione substrate (also known as 8DM). The market demand is currently high, but the price of diene has been rising, making this pharmaceutical intermediary too expensive. As a result, there is a need to manufacture a more efficient and cost-effective product in order to suit the expectations of clients.
This drug intermediate is created through mixed fermentation of Arthrobacter simplex or Bacillus megatherium, which offers the advantages of low production cost, rapid and high bio-transformation rate, high yield, and environmental friendliness. Furthermore, this product serves as a good working standard and can be utilized for internal validation in accordance with FDA regulations/guidelines. Consider Dexamethasone CAS 50-02-2 as well.
Dexamethasone intermediate CAS 24916-90-3 is a type of major pharmaceutical intermediate that is frequently utilized in the pharmaceutical business. It is found in a variety of medications, including antibiotics, antibacterial treatments, and steroids. It possesses anti-inflammatory and antioxidant properties in particular. It also possesses antiallergenic and suppressive properties.
This medication is in high demand. It is mostly used to treat inflammatory illnesses such as asthma, rheumatoid arthritis, and others. It has the ability to suppress the immune system in order to aid patients in their recovery from disease. It can also be utilized as a life-saving medication for critically unwell patients.
Dexamethasone should be kept in a tightly sealed container before storage. This will keep it from becoming contaminated or losing its effectiveness. It should also be kept in a cold, dry, low-humidity environment. This will increase the product's shelf life.
The product must be stored in a dark, cold location away from intense light and heat sources. This will also prevent tampering with any damage to the goods.
The temperature of a bottle of dexamethasone intermediate CAS 24916-90-3 in the freezer should not exceed -20u00b0C. Storage time can be extended for up to a year.
After storing the goods in a cool, dark, and dry location, it must be appropriately labeled. The labeling should include the drug's name, the manufacturer's name, the strength, and the expiry date.
It should also have a caution label on it. The drug's label should declare that it is not intended for use by youngsters or pregnant women. It should also provide product usage instructions.
It is critical to monitor the patient's status while using the medicine. It is critical to determine whether the patient is allergic to dexamethasone, as this may impair its effectiveness. It is also critical to keep track on the patient's weight, as dexamethasone can cause weight gain.
It is also vital to periodically check the patient's blood pressure and blood sugar level. It is also critical to ensure that the medicine is only taken in the prescribed amount.
With or without refrigeration, Dexamethasone Intermediate CAS 24916-90-3 is physically and chemically stable for up to 91 days. The presence of a chemically inert excipient, notably Ora-Sweet and Ora-Plus, contributes to this shelf life.
After 91 days of storage at 4degC and 25degC, the stability of suspensions made with 0.5 and 1.0 mg/mL of dexamethasone in Ora-Sweet and Ora-Plus was evaluated. The suspensions were examined using a high-performance liquid chromatography - ultraviolet detection method to assess changes in color, taste, odor, precipitation (and ease of resuspension).
Despite the presence of excipients, solutions of dexamethasone at 0.5 and 1.0 mg/mL were physically and chemically stable for up to 91 days when maintained in polypropylene syringes at 25degC or 4degC under typical fluorescent lighting. The suspensions retained at least 90% of their initial concentration across the 91-day period, despite minor changes in color, taste, odor, and precipitation.
Injection combinations including Dexamethasone sodium phosphate and ketamine hydrochloride in 0.9% sodium chloride injection were also tested for stability after up to 192 hours of storage at 25degC and 4degC. (8 days). Suspensions were judged stable if they retained at least 90% of their initial concentration and did not vary significantly in pH, color, taste, odor, or precipitation during the 192-hour period.
The addition of a physical inert excipient, such as Ora-Sweet or Ora-Plus, is crucial in maintaining suspension stability. This inertness is especially relevant when combined with the presence of a volatile molecule like ketamine hydrochloride, which degrades quickly when exposed to light. The inclusion of an antibacterial agent, such as benzalkonium chloride, improves the stability even further.
Hunan Yuxin Pharmaceutical Co Ltd., founded in 2002, is a large pharmaceutical company that specializes in steroid and hormone API and intermediates. Numerous products such as Fludrocortisone acetate CAS 514-36-3 received certificates such as GMP, DMF Number, and WC (Written Confirmation), among others. It is a key player in the global steroid business.
The company for Dexamethasone acetate CAS 1177-87-3 has a large fermentation and synthesis capacity. It also created two research and development facilities in Changsha and at our production facility. A close connection with the University is conceivable. It operates two GMP manufacturing facilities totaling 200,000 square meters and employing 550 people.
We collaborate with our clients utilizing a variety of strategies, such as custom synthesizers, contract research, and custom manufacturing of Dexamethasone sodium phosphate CAS 2392-39-4. We would do our best to meet all of our customers' requests and would welcome any type of collaboration with friends all over the world.
Yuxin Pharmaceutical Co., Ltd. produces a Prednisolone CAS 50-24-8 and sells hormone APIs to pharmaceutical firms worldwide.
Hunan Yuxin Pharmaceutical Co., ltd. Privacy policy Terms and Conditions
EN 
ES
PT
DE
TR
FR
